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Join us. Become part of the Farnung Lab team as we explore the fascinating world of chromatin, DNA replication, and transcription. We welcome driven graduate students, postdoctoral researchers, and undergraduate students eager to contribute their unique perspectives and passion for scientific discovery. Post-docs: Individuals interested in joining the Farnung lab as a postdoctoral researcher should write to Lucas and include their CV, motivation for applying, and contact information for 3 references. PhD students: Individuals interested in pursuing a PhD degree in the Farnung lab should apply through the Biological and Biomedical Sciences (BBS) Program at Harvard and The Harvard Biophysics Graduate Program. Undergraduate students: Individuals interested in joining the Farnung lab as a undergraduate researcher should write to Lucas and provide a statement of interest and motivation for applying. Lucas_Farnung AT hms.harvard.edu Twitter https://www.farnunglab.com/research daily 0.75 2025-04-24 https://images.squarespace-cdn.com/content/v1/5e9d8501956c9f3970460991/213ce03f-dd23-49f9-838b-fc8c9c3e8c41/Transcription.png Research - Understanding molecular mechanisms at the intersection of chromatin & transcription The Farnung Lab answers key mechanistic questions at the intersection of chromatin, transcription, and replication. We employ biochemical, biophysical, machine learning, and structural biology approaches to understand how the transcription machinery, histone modifying enzymes, chromatin remodelers, and the nucleosome interact to regulate gene expression. In parallel, we investigate how epigenetic information is retained during DNA replication. https://images.squarespace-cdn.com/content/v1/5e9d8501956c9f3970460991/0c4d7951-4568-4206-b53a-55cac77c618a/Rewrapped_EC.png Research - Elucidating transcription through chromatin with visual biochemistry Our research combines state-of-the-art biochemistry and cutting-edge single-particle cryo-electron microscopy to generate molecular movies depicting the transcription machinery traversing its native chromatin templates. Our work uncovers how chromatin organization is maintained and epigenetic information preserved. https://images.squarespace-cdn.com/content/v1/5e9d8501956c9f3970460991/3e8d74db-4dbe-42b0-abff-09996b938cc8/replication.png Research - Dissecting genome duplication in a chromatin context We investigate how the eukaryotic replisome navigates nucleosomal templates during genome duplication. Using in vitro reconstitution, in silico structure prediction, and pseudo-time resolved cryo-EM approaches, we visualize replication intermediates at near-atomic resolution. These structures uncover the molecular strategies by which the DNA replication machinery engage and retain nucleosomes to achieve epigenetic inheritance. https://images.squarespace-cdn.com/content/v1/5e9d8501956c9f3970460991/bce66e24-d0df-4527-8729-f37ddb4f8682/Nucleosome-CHD4.png Research - Unraveling the function of chromatin remodelers ATP-dependent chromatin remodelers play an important role in maintaining genome organization and providing accessibility to genomic information. We aim to better understand how chromatin remodelers are recruited to specific genomic loci to shape cell fate decisions, embryonic development, and cell homeostasis. To do so, the Farnung lab employs biophysical methods and structural biology approaches. 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